This study examines the determinants of effective of zakat management in Waqf and trust commission Zanzibar. The researcher has mainly employed quantitative research approach with appropriate method of analysis for this study. The sample size for this study consists of 152 respondents using simple random sampling technique and survey questionnaire was used as data collection instrument. To achieve reliable results, descriptive statistical techniques and regression analysis techniques were used to analyses the collected data from relevant respondents. The study has revealed that more than 60 percent of the total respondents have agreed and strong agreed that, Zakat knowledge, decentralization and corporatization have an impact on effective Zakat management at Waqf and Trust Commission Zanzibar. Also, the result from regression analysis showed that two predictors (Zakat decentralization and Zakat knowledge) had a significant contribution on the outcome variable (effective zakat management) while one predictor variable that is Zakat Corporatization did not show any significant result. The study concluded that the impact of zakat decentralization and zakat knowledge on effective zakat management Waqf and Trust Commission Zanzibar was in a positive direction. Finally, the study recommended that the concept of decentralization on Zakat management and administration could be implemented and started from the mosque.